Best Over the Counter Phentermine Alternatives

Have you ever heard of the Adipex-P or Lomaira weight loss pills? If so, they are phentermine (or amphetamine-like) diet pills prescribed by doctors to suppress appetite for weight loss results. Speaking of results, the average weight loss under these pill types within the first three months is 3% of initial body weight and 5 to 7% after six months [1]. Unfortunately, the benefits are attached with some disadvantages. For starters, this solution isn’t openly available to everybody.

As a qualification requirement, the body mass index (BMI) must measure at over 30, and for people with a BMI of 27 or above, proof of failed attempts at weight loss must be provided. Then, there are side effects, which aren’t any prettier since they range from dry mouth, restlessness, and insomnia to tingling feelings and increased heart rate.

So, what now? Our editorial team has crossed paths with five natural supplements that serve as suitable alternatives to phentermine. How so? In general, we sought formulas that target weight loss in varying angles (i.e., sustained satiety, increased fat burning, desirable energy levels, and suppressed appetite). Most of all, we concentrated on ingredients that decrease the risk of unwanted side effects while tending to people of different BMIs. Without any further delay, here are our top phentermine alternatives available today.

The Top Phentermine Alternatives of 2022

Before looking into the process that led us to these findings, we thought it would be a great idea to provide an overview first. This includes company background, listed ingredients, and any other justification that might support one’s decision. Let’s cut right to the chase:

  • PhenGold
  • PhenQ
  • Phen24
  • PhenAprin
  • Phena-Lean


  • Company: Health Nutrition Limited
  • Starting Price: $59.99

Allegedly backed by science, PhenGold is a multi-action weight loss formula intended to enhance the body’s natural fat-burning capacities, reducing cravings and boosting the metabolism, mood, and energy levels. Developed by the team at Health Nutrition Limited, PhenGold might extend to assist those who have been frustrated by plateaus and unnecessary setbacks.

As for the formula, it has been devised with seven steps in mind. First, the included ingredients are reckoned to turn the switch on for a fat-burning hormone. In so doing, a breakdown of fat is encouraged while restricting storage. From there, a metabolic surcharge can be anticipated, followed by a curb in appetite, increased energy, and a healthy mood. Together these facets are meant to motivate individuals and ensure they are focused on reaching their goals.

Now for the PhenGold serving, each capsule is said to deliver a significant concentration of Green Tea (500mg), Green Coffee (100mg), L-Theanine (250mg), L-Tyrosine (350mg), Rhodiola Rosea (250mg), Cayenne Pepper (200mg), caffeine (225mg), and DMAE (150mg). Secondary ingredients include Vitamins B3, B6, and B12. Here’s what the Health Nutrition Limited team has to say, “We want you to feel confident as us that when you purchase PhenGold, you’re getting one of the most powerful, effective and scientifically proven weight loss supplements on the market.”


  • Company: Wolfson Brands (UK) Limited
  • Starting Price: $69.95

The next supplement to have made the cut is the second of Wolfson Brands (UK) Limited called PhenQ. This right here is a dietary supplement that might release fat and shrink its storage, suppress appetite, and barricade future consequences of fat storage. Like most of the picks found in this guide, PhenQ also appears to have been supported by science, which the manufacturer made explicitly clear by citing several references. Why might one consider the PhenQ formula? Each serving reflects the union between L-Carnitine Fumarate (150mg), Caffeine Anhydrous (142.5mg), A-Lacys Reset (25mg), Nopal derived from Capsicum Extract (20mg), Niacin Powder (8mg), Piperine Extract (4.5mg), and Chromium (3mg).


  • Company: Wolfson Brands (UK) Limited
  • Starting Price: $74.99

Manufactured and supplied by Wolfson Brands (UK) Limited, based in Glasgow, Phen24 is a 24-hour weight loss solution split into two dietary supplements. CEO Stewart Lochrie pledges that his tight-knit team brings together entrepreneurs, marketers, nutritionists, engineers, designers, and business explorers. They share one common goal: “We want to positively disrupt the wellness industry we see today.”

To date, their efforts in relying on cutting-edge science and time-tested strategies led them to deliver solutions in the form of supplements, foods, and beauty products. Since our intention for this guide was to seek phentermine alternatives, our ranking system led primarily to Wolfson Brands (UK) Limited, where Phen24 was the first to have qualified.

A certified herbalist, nutritionist, naturopath, and formulator, Angela MacRitchie, insists that Phen24 is equipped in a way that “heightens the thermogenesis process according to your sleep and wake cycle.” Explicitly, select ingredients have been isolated to work with the metabolism while accounting for different stress levels and times of the day.

For those of you wondering what it is that permits Phen24 to work around the clock, it has to do with the Daytime and Nighttime formulas. Starting with the Daytime formula, each serving (i.e., one capsule) includes Zinc (15mg), Manganese (2mg), Copper (1mg), Iodine (150mcg), Caffeine (150mg), Guarana Extract (100mg), L-Phenylalanine (70mg), and Cayenne Powder (20mg).

On the other hand, we have the Nighttime formula bringing together the likes of Ascorbic Acid (80mg), Calcium D-Pantothenate (10mg), Pyridoxine HCl (5mg), Thiamine HCl (4mg), Chromium (120mcg), D-Biotin (120mcg), Molybdenum (100mcg), Glucomannan (1000mg), Griffonia Extract (52mg), Choline Bitartrate (40mg), Green Tea Extract (40mg), and Hops Extract (25mg) in one capsule.


  • Company: SutraHealth
  • Starting Price: $39.95

PhenAprin is advertised as a metabolic activator that appears most beneficial first thing in the morning. When taken as directed, individuals can anticipate fat burning, a significant curb to appetite, boosted metabolism and energy levels, and continued thermogenesis, all of which point to possible weight loss results. Regarding the formula, each tablet is said to be equipped with a 540mg-proprietary blend of L-Phenylalanine, Theobromine, Caffeine Anhydrous, L-Taurine, L-Carnitine, and Dehydroepiandrosterone (DHEA).

We initially decided to include this solution based on demand, as seen on Amazon. In general, verified customers have voiced their support for this formula; however, some side effects were reported (i.e., jitters, dizziness, headaches, high blood pressure, and frequent urination). In further delving into matters, one former phentermine user claims to prefer PhenAprin because it neither induced hunger nor led to extreme exhaustion. Others insist that the reverse was experienced. In the end, results may vary from person to person, and those who thrive usually follow a healthy diet and exercise routine.

At Sutra Health, the mission “is not to just sell supplements,” instead, they are “committed to creating solutions that bring out your greater potential as well as providing you with balance and well-being.” As this is being written, their products are touted for their effective formulations manufactured in an FDA-approved facility and underwent third-party lab testing.


  • Company: Anabolic Warfare
  • Starting Price: $59.99

Phena-Lean has been designed with three goals in mind: 1) to serve as a weight loss aid (through suppressing appetite and helping attain regular metabolic rates), 2) to induce healthy surges in energy, and 3) assisting individuals in sculpting a physique of their choice. By focusing on the synergy of ingredients and introducing fast-release technology into the equation, Anabolic Warfare avows that their goals were met. Precisely, each serving (i.e., one capsule) delivers Vitamin B3 (25mg) and a 596mg Phena-Lean Blend of Caffeine Anhydrous, Di-Caffeine Malate, L-Theanine, Bitter Orange, L-Tyrosine, Theobromine, Ginseng Extract, N-Isopropylnorsynephrine, Paradoxine™, Lean GBB®, Rauwolscine, and Huperzine A.

In the context of the manufacturer, Anabolic Warfare takes pride in their offerings because their efforts are believed to push the limits so “you can push past yours.” What does this mean? From pre-workouts to muscle builders, the main similarity is their ability to tend to people who devote time to the gym as some do to the church. Through their supplements coupled with appropriate lifestyle choices, individuals can hope for consistency, safety, and primarily measurable outcomes.

The Ranking System that Led Us to The Top Phentermine Alternatives

As seen from the introduction above, finding identical formulas is impossible. Sure, there are similarities in ingredients, but each brand approaches phentermine alternatives differently. Our editorial team was quite fond of the level of diversity in our selection, given that unique angles imply increased odds of targeting various groups of people struggling with weight management. We decided to create a ranking system that factors the fundamentals in light of our goal. Explicitly:

Manufacturer Reputation & Transparency

A supplement that reflects anonymity and secrecy must be questioned and ignored when faced with ambiguity. Individuals must know its intended purpose, selected ingredients and dosing as with any dietary supplement. Most of all, they must be acquainted with the manufacturers. Why? The former demonstrates whether a solution fits on a case-by-case basis, while the latter provides peace of mind regarding legitimacy, quality, safety, and efficacy. Ultimately, the absence of a manufacturer and low levels of transparency should raise red flags in one’s mind.

Ingredients & Dosing

When on a quest for all-natural substitutes for phentermine, it only makes sense to include ingredients that work alike or produce comparable outcomes. In this case, a suppressant does not merely suffice; we would also need something that targets fat storage and low energy. Why do we need to consider different aspects? This returns to our goal of ensuring that the top contenders attack weight management from different angles. Some examples of alternatives include (but are not limited to) caffeine, green coffee, green tea, grains of paradise, and glucomannan.

Advertised Benefits

Considering the taken route, the rate at which a noticeable difference is witnessed might vary. Phentermine has been scientifically proven to elicit extensive results within a month; however, the same quality of results cannot be expected with natural, plant-based components. Thus, manufacturers’ claims were studied before deciding whether their solutions should be included. Any claims that suggested prompt results in a short period (without evidence) were neglected altogether. We neither want individuals to have the wrong idea nor encourage investing in solutions that might not meet the mark.

Customer Reviews

Customer reviews were analyzed to see the success rate for each solution. This doesn’t mean that only the highly praised supplements reviews were included. Our editorial team emphasized the negatives, primarily on the quality of results and the potential risk of side effects. That said, individuals should remain open because reviews seldomly reflect one’s lifestyle choices, health conditions, exercise, and medication intake. Negatives should be perceived as nothing more than warnings.


Uniqueness can be defined however one pleases. To us, a supplement is unique if it is likely to outperform another equivalent formula. Some facets indicating originality include scientific research, money-back guarantees, involvement of a health professional, medical or scientific advisory boards, financing options, easy ingestion, and giving back to society. We encourage everyone to reflect upon their deal breakers and include them under this large umbrella when narrowing down available options.

Value for Price

To wrap things up, we have value for the price. This answers the ultimate burning question that most of us are likely to ask, “Is the listed price justifiable?” The final answer rests in the number of factors checked off. It seems illogical for a dietary supplement to cost $69 yet does not comply with something so basic as transparency or doesn’t come with a money-back guarantee. The idea that a high price immediately implies quality has long been debunked.

What is Phentermine?

Phentermine is an appetite suppressant drug that doctors still prescribe for combating obesity. As outlined in one piece [2], it has been classified as a Schedule IV drug alongside other anorexiants and central nervous system stimulants. This classification also suggests that it may have the potential for abuse despite low cases proving so.

This drug can induce looked-for weight loss among people at risk of experiencing high blood pressure, high cholesterol, and diabetes when taken in conjunction with a diet and exercise program. Another source that factored in Meera Shah, MD’s opinion on the matters pointed out that phentermine is often the last resort for obese people with a BMI over 30 and for people who failed to see results even after tweaking their lifestyle choices. More importantly, it is unsuitable for “people who want to lose just a few pounds [3].”

What Role Does Phentermine Play in the Body?

Phentermine stimulates the secretion of an organic chemical in the catecholamine family called noradrenaline (serving the roles of both a hormone and neurotransmitter). Additionally, it has been shown to suppress appetite by regulating the beta-adrenergic (also known as beta-blockers) receptors [4]. Earlier, we introduced Adipex-P; well, this is the brand name for the FDA-approved phentermine drug, where other neurotransmitters (i.e., norepinephrine, serotonin, and dopamine) are released to decrease feelings of hunger. A caloric deficit is maintained by reducing the urge to eat, triggering weight loss [5].

What are the Pros and Cons of Taking Phentermine?

The primary benefit of taking phentermine, especially for the overweight and obese populations, rests in its weight loss results. A 2006 study investigated the short-term administration of phentermine in Korean obese people. In so doing, the mean decrease of both body weight and waist circumference was reported as being significantly greater than that of the placebo group.

Matter-of-factly, the researchers reported that a significant number of subjects accomplished weight reduction of 5% more from the baseline and 10% or more. Of the adverse effects, only dry mouth and insomnia were statistically significant, adding that most side effects were of mild to moderate intensity [6]. A 2016 study on the drug’s effect on weight reduction in a pediatric weight management clinic also reported positive results.

Precisely, differences were assessed at the one-, three- and six-month marks only to disclose a more remarkable percent change in BMI at each time frame compared to the group subjected to a standard of care lifestyle modification therapy (SOC). The researchers also discovered that heart rate was higher in the phentermine plus SOC group at all times compared to the SOC only group [7].

In search of the endless possibilities of taking phentermine, we stumbled upon a 2019 piece where Senior Investigator at Kaiser Permanente Washington Health Research Institute, David Arterburn MD, MPH, discussed reassuring news. Mainly, his team wanted to fill in the voids regarding longer-term uses. As a result, their review (encompassing 14,000 female users) led them to learn that weight loss results were better when taken over a longer-term, i.e., up to two years’ follow-up. Moreover, they did not establish any link between phentermine use and risk of cardiovascular disease or death up to three years from starting.

David also said, “As far as safety goes, we expected to see an increase in blood pressure, but instead found that systolic blood pressure was reduced at 24 months in long-term users of phentermine relative to short-term users.” Although their team did disclose that 41% of 13,972 users did experience adverse effects, it was stressed that they were not long-term users [8]. Bear in mind that this study is limited because of its observational nature rather than being a randomized controlled trial and limited sample of long-term users.

Concerning the cons, the first obvious is that it supports a determinate target population. This means that healthy people who’ve reached a plateau should not be taking phentermine. The second major con is its known side effects. Examples include shortness of breath, chest pain, nausea, dizziness, swelling in the ankles and feet, tremors, itching, dry mouth, insomnia, fluctuations in sexual desire, increased blood pressure, constipation, heart palpitations, and stomach-aches [2, 9].

What does Science Suggest Regarding Natural Alternatives for Phentermine?

Now that the basics surrounding phentermine have been covered, it’s worth the time to reflect on all-natural alternatives to the drug. Since many of our formulas contain several ingredients, our editorial team decided to research the five common elements found across them. Bear in mind that when the time to finalize decisions on a supplement arrives, individuals must do their due diligence to verify the scientific background on all ingredients. This is typically advised to prevent any health-related compromises. In keeping with those described above, here’s what our research suggests:

Caffeine Anhydrous

Caffeine anhydrous is a highly concentrated source because it has been freed of water. As for its ability to replace phentermine, one source explained that ingesting caffeine generally mimics a compound in the body called adenosine that allegedly livens things up. Additionally, it has been shown to enhance natural stimulants, including dopamine, norepinephrine, glutamate, and adrenaline [10]. Another reference that looked at the effects of caffeine concluded that it might reduce feelings of hunger, extend one’s desire to eat for a brief time, and increase calorie burning [11].

Cayenne Pepper

Spicing things up has been linked to a curb in appetite. A piece that delved into the science of cayenne pepper did so from several angles [12]. First, a 2014 preliminary study where subjects consumed red pepper with every meal revealed increased feelings of fullness and fewer cravings. A 2003 study investigating the effects of eating fresh chili pepper on the metabolism concluded that it raised metabolic rates for up to 30 minutes after consumption. The idea that it could also help burn calories stems from its potential in inducing thermogenesis, i.e., increasing the body’s temperature. Nevertheless, noticeable changes might lessen when the body becomes accustomed to cayenne pepper.


L-theanine is an amino acid that alleviates anxiety and stress on the mind and body. One study supposedly demonstrated reducing triglycerides and non-esterified fatty acid levels when coupled with caffeine. Furthermore, the duo is believed to assist in the process of lowering cellular fat accumulation. Finally, the fact that it is derived from green tea has many people suggesting that it can also reduce appetite while supporting individuals in maintaining a caloric deficit [13].


L-phenylalanine is the second amino acid to have qualified across some of our top contenders. One essay that reviewed a high-protein diet commented on L-phenylalanine and its ability to reduce food intake [14]. Regarding its driving force, they mentioned the possibility of increased GLP-1 (glucagon-like peptide 1) levels [15], which enhances the insulin hormone while curbing appetite. Lastly, one might expect a reduction in the ghrelin hormone, i.e., the hormone responsible for inducing feelings of hunger.


Like L-theanine, theobromine is a mild stimulant drug found in tea, coffee, and cocoa. Its nature has promoted weight loss by reducing hunger cries and appetite. It has also been shown to break down excess fat in the body, explains one source [16]. Other positive changes include an uplifting mood and a state of alertness. Now for its mechanism, one review highlighted that theobromine might inhibit phosphodiesterase and block adenosine (which explains the attention and feel-good experiences) [17].

Frequently Asked Questions About Phentermine Supplementation

Q: What is phentermine?

A: Phentermine is an appetite-suppressant prescription drug believed to support obese and overweight people.

Q: Is phentermine suitable for everyone?

A: No, phentermine is not prescribed to just about anyone. This drug is only approved for use in adults with a BMI of 30 or greater or adults with a BMI of 27 or greater who attempted diet and exercise yet failed to see results.

Q: Is phentermine available over the counter?

A: No, phentermine is not available over the counter; instead, it has been limited to prescription use. While there are no safe or legal OTC alternatives, individuals may also want to consider all-natural ingredients that mimic phentermines appetite suppressing, energy and mood-inducing, and weight-loss triggering characteristics.

Q: Why is phentermine described as having “some potential for abuse”?

A: Phentermine is a Schedule IV drug, i.e., a classification given to drugs with a low potential for abuse and low risk of dependence. The latter risk stems from its role as a stimulant, making phentermine a controlled substance.

Q: Are natural alternatives to phentermine safer?

A: Natural alternatives to phentermine found throughout the formulas listed above are generally safe, but only when taken at moderate and tolerable concentrations. Taking anything in excess, drug or not can have negative health consequences that could easily be avoided.

Q: Is it safe to take caffeine alongside phentermine?

A: Since caffeine and phentermine are stimulants, taking them together can lead to a significant increase in heart rate and feelings of jitters. Worst of all, this duo is reckoned to put individuals at risk of experiencing the reported side effects of phentermine.

Q: What is thermogenesis?

A: Thermogenesis is a metabolic process that increases the body’s temperature by burning calories. With a healthy diet and regular physical movement, thermogenesis can increase a caloric deficit.

Q: What lifestyle changes must one consider for healthy weight loss?

A: For a successful weight loss journey, individuals must be motivated and determined to make positive changes such as setting realistic goals, enjoying whole foods over sugars, fast food, and other junk, and ensuring that their daily requirement of water intake and physical activity have been fulfilled. Poor habits like smoking and drinking can also create setbacks for those aiming to see weight loss results.

Q: How long will it take to see results with phentermine alternatives?

A: On average, individuals anticipate seeing results with phentermine alternatives anywhere between one and six months. The rate at which one might lose weight is dependent on medical history, current health, diet type, exercise, and consistency.

Q: How does one go about finding dietary supplements that mimic phentermine?

A: The first place to start is referring to our top five phentermine alternatives. These are closest to phentermine’s characteristics yield comparable weight loss results.

The Top Phentermine Alternatives of 2022 Final Verdict

The constrained nature of phentermine puts healthy people and those with just a couple of pounds left to lose without a solution. In the case of obese and overweight people, phentermine can drive results, but whether they are worth the reported side effects should be reflected upon. Our research suggests that despite the prescription drug’s low-risk rating, the outcomes can be adverse depending on one’s case.

We sought alternatives analogously to phentermine to rid everyone of unwanted consequences. In so doing, our search led us to five natural phentermine supplements deemed fundamental for a successful weight loss journey. The main difference between phentermine and the top alternatives is that the former on its own can elicit weight loss, whereas the latter is meaningless alone.

Individuals must pair natural alternatives with an appropriate diet and workout routine for natural options to work. This is something that people tend to neglect, forcing them to believe that the problem rests in the formula and not the routine. From the scientific angle, the commonly included ingredients have value to bring to one’s journey, which we were content to see. But the journey will be different from person to person, and this is something to hold onto while getting started. Until we revisit the top phentermine alternatives, we hope that at least one of our picks resonated with set goals.


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