Best Estrogen Blocker for Men Over 40 (Top Supplements List)

In this article, we review the best estrogen blocker on the market, and we go over what exactly estrogen blockers are? What do they do? And how do they help men boost their testosterone?

Testosterone is a male sex hormone critical for sexual and reproductive development. It plays an active role in maintaining muscle mass and strength, including enhancing sex drive, improving sperm production, and overall men’s health.

Estrogen blockers are similar to testosterone boosters. Their job is to help balance the hormones when testosterone levels drop due to many factors. But the difference with testosterone boosters is that estrogen blockers, as the name suggests, achieve this balance by inhibiting estrogen.

With many products on sale, it has become necessary to list the best estrogen blockers in the market. This supplement list is the product of researching the best-reviewed estrogen blockers from the most reputable sources.

In a rush? Here are the best estrogen blockers:

The Best Estrogen Blockers

While PrimeGENIX DIM3X is our top recommendation, we also recommend Provacyl as a good alternative for reversing andropause.

  • PrimeGenix DIM 3X
  • Provacyl

Let’s dig deeper into each of these two alternatives.

PrimeGenix DIM 3X


Many products claim to reduce estrogen levels naturally, but PrimeGENIX DIM 3X backs it up. One of the newest estrogen blockers on the market, the supplement also works as an aromatase inhibitor, preventing the conversion of testosterone into estrogen.

How It Works

  • PrimeGenix DIM3X works in three different ways to stabilize hormones in the body.
  • Balancing Estrogen Levels – converting bad estrogen to beneficial estrogen for men
  • Blocking Aromatase Enzymes – prevent testosterone from converting to estrogen.
  • Supporting Testosterone Production – additional hormone support

Aromatase is an enzyme that transforms “male” hormones in the body into estrogen. Aromatase inhibitors are common treatments for women with breast cancer and work to help increase or stabilize testosterone in the body.

Most of us think of testosterone as the vital ingredient for male libido, but estrogen plays an important role. PrimeGenix DIM3X helps balance all the essential hormones so you can be your best self.

How It Is Made

PrimeGENIX DIM3X is 100% natural and manufactured in a cGMP facility. The supplement is rigorously tested for purity, quality, and safety. These ingredients include DIM, BioPerine, AstraGin, and Vitamin E.

So far, there have not been reports of side effects because the supplement contains only natural ingredients that work with the body, not against it.

Who It Is For

PrimeGenix DIM3X is best for men 40 years of age and older looking to balance their hormone production. The all-natural supplement will help increase focus and concentration and boost energy, stamina, and strength.

The supplement helps to block estrogen production while supporting hormonal balance. The capsules reduce male breast tissue, increase fat metabolism and enhance libido.

PrimeGenix DIM3X can help men over 40 with the following issues:

  • Fatigue or feeling sluggish
  • Weight gain
  • Irritability
  • Low libido
  • Difficulty building muscle and strength
  • Mental fog

How To Take It

DIM3X has 120 capsules per bottle with four tablets per serving. Consistent intake of this supplement will decrease lethargy, erectile dysfunction, insomnia, and gyno.

No prescription is necessary to add this to your diet, and the supplement includes a risk-free 67-day trial. If you aren’t satisfied with your results within 67 days, you can receive a full refund.


  • 100% natural ingredients and formula
  • No unwanted harmful or side effects
  • Boosts testosterone for strength, stamina, and energy
  • Balances estrogen for healthy sexual function
  • Supports weight loss and fat burning
  • Help increase daily energy and mental focus


  • Only available online
  • Results may vary



Provacyl is arguably one of the most recommended supplements for men looking to enhance their hormone levels. Male andropause is inevitable for men with decreasing levels of sexual desire and changes in body composition.

How It Works

Andropause – also called “male menopause” – occurs when men experience a sudden drop in testosterone levels and symptoms.

Andropause can occur because of aging but may also be related to diet, environment, and other lifestyle factors. The symptoms can include:

  • Weight gain
  • Loss of mental sharpness
  • Loss of sexual interest
  • Muscle weakening
  • Fatigue

Provacyl reverses the adverse effects of the male aging process. Many users experience an uptick in sex drive and increased muscle mass. Provacyl users are less likely to suffer depression and report smoother, clearer skin. Some of the ingredients in this supplement include:

  • Vitamin D3
  • Vitamin K2
  • “ZMA” – a powerful combo of zinc, magnesium, and B6
  • D-Aspartic acid
  • Ginkgo Biloba
  • Korean Panax Ginseng
  • Acai Fruit Berry

Provacyl has many natural ingredients that help improve physique, core strength, and general health. The supplements’ nutrients help trigger the body to produce more HGH and testosterone – the hormones that decrease in the case of andropause.

How It Is Made

The ingredients in Provacyl work in four different ways to support hormone balance.

“ZMA” – This ingredient packs a punch of zinc, magnesium, and vitamin B6. This combination of nutrients has shown promise as a hormone balancer and testosterone booster.

Effective Dosage – The dosage in Provacyl puts years of study into practice and maximizes the benefits you feel.

Quality Ingredients – Leading Edge Health produces Provacyl in a CGMP-compliant facility located in the United States. We’ve seen excellent quality ingredients from the brand in every product.

Money-Back Guarantee – We love that Leading Edge Health includes a 67-day satisfaction guarantee. If you aren’t happy with your results within the time frame, you’ll get your money back.

Who It Is For

Provacyl is ideal for men 50 and older or anyone experiencing longer-term dips in HGH or testosterone. The nutrients will help your body naturally begin producing these two hormones again.

How To Take It

Always follow the manufacturer’s instructions on any supplement. Provacyl comes in tablet form, and the recommended dose is two tablets daily – one tablet in the morning and one tablet at night.

The effects will build over time. At six months, you should be feeling at your peak performance.


  • Enhanced HGH and testosterone helps ward off common ailments
  • Natural nutrients and ingredients
  • The high-quality manufacturing process
  • No prescription necessary
  • Satisfaction guarantee
  • Improved muscle mass
  • Improved libido
  • Burn body fat


  • Newer product without FDA approval
  • It may not work for everyone

How To Find Best Estrogen Blocker

There are so many estrogen blockers on the market that it can be challenging to find the best type to buy for your needs. You’ll need to consider your specific health, goals, and the product claims of each estrogen blocker you’re considering.

Here are the most important factors to consider before making your purchase.


The best estrogen blockers are often slightly more expensive due to the quality of the ingredients and standard of preparation. You want to look for natural ingredients free of toxins or harmful preservatives.

Estrogen blockers like PrimeGENIX DIM3X are made in a cGMP facility for the highest quality, safety, and purity. The price is reasonable for the quality.


Another factor worth considering is the brand. Different sellers sell many estrogen blockers, and it is critical to know each brand type to get the right product.

Look for brands that have certifications and good reviews. US-based brands are often a better bet.


Estrogen blockers often have a specific function, which depends on the ingredients. The higher quality ingredients most likely provide better functionality, as well.

Ask yourself why you need an estrogen blocker? What circumstances led you to search for products?

If you’re experiencing andropause as you age, you will want a product specifically formulated to reverse the effects of andropause.

If you’re experiencing muscle weakness, lower sex drive, or weight gain, you may want to look at different formulations for the proper hormone balance.

Your Health & Goals

Before making a final decision, you should map out your goals for yourself. Do you want to increase HGH and testosterone? Balance estrogen in your system? How long are you willing to try an estrogen blocker?

An essential part of your health is to choose natural ingredients that work with your body, not against it. Natural ingredients with high nutrition will help your body adjust over time – with a goal toward permanent improvements.

When To Take Estrogen Blockers

There are a couple of different times you may want to consider estrogen blockers. Here are the main two reasons.

Support Post Cycle Therapy

The primary reason to take estrogen blockers is to support a post cycle therapy (PCT) after a prohormones cycle.

Anyone who has gone through a prohormones cycle without proper preparation will know how bad it can feel when you stop the process.

At the end of the four weeks, you’ll feel great, but as you end the cycle, if you don’t take care to balance your hormones, you may notice a drop-off in strength, muscle mass, etc.

Estrogen blockers are a common way to support your PCT. You can even use them during the cycle or in any of the following methods:

Some users may take them from day one of PCT

Some may wait until the third week when they believe hormonal changes occur.

Others may keep it on hand during their cycle if they notice some side effects, so they can take the estrogen blocker to reduce these issues.

Reverse Andropause

Some men may experience unwanted loss of muscle bulk, sex drive, or the ability to lose weight. If you can trace the symptoms to a drastic and sustained drop in hormones, you might be experiencing andropause.

Estrogen blockers can be a great way to reverse these effects when used correctly.

Estrogen Blockers Dosage & Directions

Many estrogen blocker brands advise taking these supplements for four to six weeks. The estrogen effects are likely to reduce towards the end of the cycle. However, it is still essential to follow the directions on the container and discontinue use if side effects persist.

According to research, users can take 50-300 mg daily DIM. However, this is following several cancer studies, not an overall health analysis.

Whatever product you choose, the manufacturer should include dosage instructions on the packaging. Always be sure to consult these instructions or a nutritionist when you start a cycle of estrogen blockers.

Remember that the effects will take time to show. Be patient and be consistent.

Reasons to Take Estrogen Blockers

Excess estrogen is something no one needs. Even for women, an imbalance of estrogen is a bad thing. Some of the side effects include:

  • Female breast tissue growth (gyno)
  • Bloating and excess water retention
  • Reduced libido
  • Depression

While some estrogen levels are essential for all genders, you need to ensure you are in the right balance. Depending on other lifestyle choices, you may need help to block estrogen production for a short or long period.

Best Ingredients for Estrogen Blockers

The ingredients play a huge role in determining the quality of the estrogen blocker, and natural ingredients are less likely to have harmful side effects.

The best ingredients work naturally with your body to help produce the hormones you need most safely. Here are a few of those key ingredients to be on the lookout for.

Diindolylmethane (DIM)

DIM is one of the most effective ingredients to decrease estrogen levels. There are many studies on DIM, primarily due to its presence in superfoods like broccoli and kale. According to the Thyroid Journal, DIM modulates estrogen metabolism.

Studies show that DIM may help prevent cancer and diseases linked to estrogen. DIM can produce the following benefits:

  • Support weight loss
  • Help with memory and mental sharpness
  • Slow cancer cells related to estrogen
  • Reduce toxins
  • Boost mood balance
  • Improve prostate health
  • Support muscle growth
  • Boost antioxidants


Bioperine allows the body to absorb the other ingredients in more significant amounts. It is an extract of the black pepper that makes estrogen-blocking results more effective.

Bioperine has several other potential health benefits, including:

  • Reducing inflammation
  • Increasing nutrient absorption
  • Supporting brain function
  • Controlling blood sugar


AstraGin is a natural nutraceutical compound that consists of ginseng and astragalus. It helps absorb specific nutrients to ensure users get the most out of the estrogen blocker.

One of the primary nutrients that AstraGin helps absorb is the branched-chain amino acid (BCAA) leucine. Leucine is critical for muscle protein synthesis.

It also helps with sleep function, which is key to physical performance.


The main ingredient in aromatase inhibitors, Arimistane, is commonly used to stop estrogen build-up and enhance testosterone levels by preventing the conversion of testosterone to estrogen. It is also helpful in the reduction of cortisol levels.

However, the ingredient is banned by the World Anti-Doping Agency (WADA), so do not use anything with this ingredient if you compete.

Vitamin E

This powerful antioxidant helps remove estrogen from the body and supports immune function, skin and organ health, and overall energy.

Estrogen Blockers FAQs

Q: What Is an Estrogen Blocker?

A: Estrogen blockers are compounds or chemicals that either decrease estrogen production or prevent the activity of estrogen in the body.

Estrogen is a female sex hormone that inhibits the effects of male sex hormones. The best estrogen blockers like PrimeGENIX DIM3X only use natural ingredients to decrease estrogen levels.

Everyone has some estrogen in their body, but those levels can get out of balance for some of us. An estrogen blocker helps reinstate balance.

Q: Who Should Buy an Estrogen Blocker?

A: Bodybuilders and athletes may use estrogen blockers and combine the supplement with testosterone boosters to boost muscle size and energy levels.

Others may use estrogen blockers to help erectile dysfunction and increase libido levels, significantly improving male sex drive.

Estrogen blockers can also help with weight loss and reduce the appearance of “man boobs.”

Q: What to Find in an Estrogen Blocker?

A: Many brands recommend consulting a medical professional before taking any estrogen blocker supplement. We agree that you should consult with a doctor or nutritionist to ensure an estrogen blocker is right for you.

Once the user gets the go-ahead, it is vital to avoid any supplement that contains additives, flavoring, or other artificial chemicals.

Q: What is the Side Effect of Estrogen Blocker?

A: Users who take estrogen blockers as directed by the bottle or recommended by a healthcare provider will experience little to no side effects. However, it is possible to experience mood swings, nausea, and headaches related to changing hormone levels.

Speak to your doctor if you experience side effects.

The Best Estrogen Blockers Conclusion

Estrogen blockers help regulate estrogen levels, boost physical performance, and reduce muscle loss.

Males with high estrogen levels are likely to have low testosterone levels, and estrogen blockers may help to restore hormonal balance.

We recommend two of the best estrogen blockers on the market, PrimeGENIX DIM3X or Provacyl, for an all-natural, nutrient-based approach to finding your balance.

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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