Best Hangover Supplements 2021 Top Hangover Prevention Pills

Getting a hangover is a common occurrence, especially after a great night out alone or with friends. However, nobody likes the aftereffect feeling that lingers on several hours after the party. Fortunately, people can prevent hangovers by taking the right supplements before, during, and even after drinking.

Hangover pills are made from vitamins, minerals, and herbal extracts, among other ingredients. The ingredients defend the body from the effects of partying. Some hangover supplements deliver B vitamins, which prevent headaches and dehydration. Some supplements focus on preventing alcohol hangovers, while others can work for all types of hangovers regardless of how hard one parties.

With so many hangover pills on the market, consumers often find it challenging to know which one is right for them. To close this gap, this list provides a cluster of the best hangover pills to consider buying in 2021. We developed this list after several hours of deliberation and testing of actual products.

Best Hangover Supplements in 2021

After poring over lab reports, consulting manufacturers, and testing actual products, our editorial team ranked the best hangover pills as follows:

  • AfterDrink
  • FlyBy
  • MoreLabs Morning Recovery
  • Drinkwel
  • PureWine
  • DrinkAde
  • Cheers
  • Over EZ
  • Blowfish
  • The Plug
  • Zaca
  • NoDaysWasted DHM Detox Recovery Blend
  • Toast
  • LiquidIV Energy Multiplier
  • Purple Tree
  • Sobur Hangover Support
  • Fewer Regrets

To learn more about these products, here is a rundown of each hangover supplement:


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The AfterDrink hangover supplement delivers 23 vitamins, antioxidants, and herbal extracts to help users wake up to a better morning. Available in a convenient and transparent capsule, this supplement is a great weekend companion that restores and replenishes the body after a moment of partying.

According to the manufacturer, it supports metabolism, mental performance, and liver function. The supplement is made from natural ingredients with zero fillers and maximum antioxidant properties. It gives users enough antioxidants to support normal inflammation throughout the body, making it easier for them to recover after a night of heavy partying and drinking.

The main ingredients in AfterDrink are DHM, ginger, and milk thistle. On this list, it’s one of the best-value hangover pills, going for $35 per bottle.


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The FlyBy is among the best hangover brands to consider in 2021. It offers a range of supplements that target recovery, fuel, and overall health and wellness. In the hangover supplements space, FlyBy provides Recovery capsules, which are made from natural ingredients to help users seize the day after a night of drinking.

Currently priced at $35 per bottle, Recovery uses natural ingredients to help restore the body and balance. Each bottle contains 90 capsules to give users enough power to feel great. According to the manufacturer, the FlyBy Recovery hangover supplement delivers ingredients that replenish vital nutrients and support healthy liver function.

With science-backed ingredients, the formula can also reduce post-drinking drag. The main ingredients in the formula are B vitamins (vitamins B1, B2, B6, B9, and B12), amino acids, DHM, milk thistle, prickly pear, and other natural ingredients. Most importantly, FlyBy is the only company on this list that runs a clinical trial on its product. The product is currently priced at $35.

MoreLabs Morning Recovery

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The Morning Recovery hangover supplement from MoreLabs embraces a proprietary blend of electrolytes to help users hydrate and feel good after a night of partying. The manufacturer recommends taking one dose of Morning Recovery before the first drink to prevent the aftereffects of drinking.

The formula works well with various drinks to block hangovers, including wine, beer, spirits, and cocktails. Morning Recovery contains a combination of herbs, vitamins, adaptogens, and minerals to help users feel better. The manufacturer, More Labs, guarantees users will feel better with the formula—or they can get their money back.

MoreLabs Morning Recovery commands an average rating of 4.9 stars out of five and several positive customer reviews. This makes it one of the best-known and best-rated hangover pills on the market today. It’s currently priced at $36.


Drinkwel is another hangover supplement to consider using in 2021. The formula uses vitamins and minerals to refill nutrients, process toxins, and support liver health. In addition to the hangover supplement, the company offers a range of supplements for overall health and wellness.

The flagship supplement contains taurine, NAC, alpha-lipoic acid, milk thistle, green tea extract, DHM, L-theanine, and significant doses of several vitamins and minerals. It works as a multivitamin combined with a Detox formula. Besides, it delivers some of the most potent dosages and most proven ingredients on this list, making it one of the best hangover pills available on the market today. Drinkwel is currently priced at $40.


PureWine is the only hangover supplement and brand on this list that targets hangovers caused by wine. According to the official website, it can physically remove hangover-causing compounds arising from wine. Instead of taking the supplement before or after drinking, the manufacturer recommends taking the formula while drinking.

The products from PureWine use a patented Phoenix filtration system to eliminate sulfites and histamines from wine. This supplement is ideal for those who frequently get wine headaches, often caused by histamines or sulfites in wine. Besides, PureWine’s products have an added advantage: they remove oxidized elements from wine.

This is important for users trying to revive an old bottle of wine, as the PureWine supplement can remove the oxidized elements and leave them great-tasting wine. The company provides two filters—The Wand for filtering each glass and The Wave for filtering each bottle. PureWine products are priced from $12 to $25.


DrinkAde is a hangover supplement that works to help the body neutralize toxins and rehydrate. In addition to alleviating the aftereffects of drinking, this supplement delivers other health benefits. Users can take DrinkAde to support an active lifestyle or help their bodies recover after a workout.

This supplement is ideal for those experiencing a hangover after heavy drinking or being stressed with life or the workplace. DrinkAde is also among the most recognizable hangover supplements on the market. Users can easily spot it on various shelves of various stores nationwide.

The supplement is available in two varieties: Prevention and Boost. The first is a caffeine-free, limeade-flavored preventative measure, while the latter is a hangover capsule with caffeine and B vitamins to restore the body the morning after.

Currently, DrinkAde is priced at between $4 and $5 per serving, according to whether one buys a 6-pack, 12-pack, or 24-pack. The overall price ranges from $28 to $97, making it one of the more expensive options listed here.


The Cheers brand is the provider of three hangover supplements that work in different ways. The company offers an after-alcohol aid known as Restore, an oral rehydration solution called Hydrate, and a daily liver supplement known as Protect. The supplements are priced from $20 to $35 per bottle and work best when taken before sleeping.

Users can boost their bodies’ defense against hangovers while remaining hydrated by taking different Cheers supplements before sleep. It could also help protect the liver, alongside other benefits. Notably, the company makes its products in the United States using proven ingredients such as DHM.

As of 2021, Cheers has sold more than 14 million supplements. It has also received a patent on its Vitamin B2 blend, something missing from any other company on this list. For these reasons and more, Cheers continues to be among the best hangover pills available today.

Over EZ

Over EZ is a vitamin that works to prevent hangovers before they happen. The products are priced between $20 and $144 per bottle, supporting between 8 and 72 hangovers. The formula uses natural ingredients to prevent users from getting the aftereffects of alcohol.

According to the manufacturer, users should take one capsule of Over EZ at least 15 minutes before their first drink. The supplement not only prevents hangovers but also helps boost the immune system during the drinking session. It accelerates the breakdown of hangover-causing toxins and helps users wake up feeling alive and energized. Importantly, Over EZ is also among the few hangover supplements on this list that users can get through Walmart, Amazon, and other major online retailers. The products are priced at between $20 to $244.


Blowfish is a hangover supplement that works to restore balance and eliminate the aftereffects of drinking. The product is science-backed, FDA-recognized, and promises to make users feel better within 15 minutes. The supplement is available at various affordable prices, starting from $15 for a starter pack to $100 for a Double Party Box, among other options.

Additionally, this formula is unique because users should take it after the hangover has set in. While other supplements focus on preventing a hangover before it occurs, Blowfish can quickly turn around the user’s day with a hangover-free guarantee.

The formula uses an effervescent tablet that makes users feel human again even if they forgot to take a hangover pill the previous night. The product price ranges from $15 to $60.

The Plug

The Plug hangover pill claims to support productivity levels while supplying the body with the nutrients it needs to remain hydrated. The Plug is also a plant-based hangover supplement that contains up to 13 herbs, fruits, and flowers mixed with bedrock water to help users feel the best version of themselves.

Users can find the Plug supplement from convenience stores across the USA, and the company is expanding its rollout nationwide. As the best-known official partner of the UFC, The Plug delivers ingredients such as licorice root, dandelion, Schisandra, purslane, honeysuckle flower, oriental raisin tree (DHM), and other similar and unique ingredients.

The formula offers 25 calories per serving with no caffeine or added sugar. With these qualities, the supplement’s popularity is rising as one of the best hangover pills on the market. The product sells for $35.


The Zaca hangover supplement targets hydration and the liver. Zaca is available in chewable tablets, which users can put in their mouths to fight dehydration and hangovers. Like other hangover formulas listed here, Zaca is advertised as a general recovery aid, which consumers can apply as a pre or post-workout formula.

It combats overheating and is helpful for travel and altitude, among other uses. Zaca delivers natural ingredients such as Japanese raisin, L-glutamine, L-glutathione, and prickly pear. The proven ingredients in this formula support the liver and hydration while giving the users the ingredients they need to fight hangovers.

Importantly, Zaca delivers antioxidants, amino acids, herbs, and plants, to give users the hydration and liver support they need to stay balanced and steady after a night of heavy drinking. The Zaca hangover formula currently costs $21.


This hangover supplement has been marketing itself across the internet recently with trendy packaging and natural ingredients. NoDaysWasted delivers ingredients like DHM and works similarly to other hangover pills listed here. It works to fight toxins such as acetaldehyde that the body generates while drinking. Studies have shown that DHM can fight this toxin.

Importantly, NoDaysWasted is another plant-based blend that contains L-cysteine, DHM, milk thistle, organic prickly pear, sodium, B vitamins, and potassium. The manufacturer recommends taking two capsules of the supplement with water during a night out or before sleep.

For heavy nights, users might need more than two capsules. The product is available at $34 for a packet of ten pills, making it one of the more affordable hangover supplements listed here.


Toast makes a variety of berry-flavored gummies, which are based on the latest hangover science. It uses natural ingredients such as milk thistle and matcha to eliminate the aftereffects of drinking. Toast is available in a pocket-sized pouch that offers two servings. This makes it easy to take the gummies on the go.

Users just need to take one serving of five gummies before drinking. For heavy nights, they can take up to one more serving of five more gummies. Toast is currently priced at $30 for 12 servings, making it one of the affordable packages of hangover supplements on this list. The pre-drinking gummies were found on the idea that users should toast their health before their drink—hence the name ‘Toast.’

LiquidIV Energy Multiplier

This hangover supplement is an energy drink blend that increases energy using proven natural ingredients. After a hangover, users need to mix one packet of the LiquidIV Energy Multiplier formula with water and then drink it to power their bodies.

While it’s not marketed as a hangover supplement, the Energy Multiplier formula is popular for its ability to support post-drinking hydration and energy. It’s ideal for those who want to boost their energy in the morning after heavy drinking. Each serving delivers about 100mg of caffeine together with proven energy boosters like guayusa, matcha, and ginger.

The supplement ensures the users can remain active the day after a heavy night out by supplying the body with adequate antioxidants, caffeine, and other energy sources. A packet of the Energy Multiplier supplement goes for only $25, equivalent to 14 servings. It’s, therefore, one of the more affordable options on this list.

Purple Tree

Purple Tree markets its products as “Celebration Vitamin” capsules. Users can buy the formula in two different forms: as hydration drops or as capsules. When added to 16oz of water, hydration drops can help hydrate the body and prevent specific hangover symptoms. On the other hand, the capsules deliver the same ingredients in capsule form.

By taking hangover supplements from Purple Tree, users can promote healthy liver function and refill the essential vitamins and electrolytes lost during drinking. The users can therefore enjoy better mornings. Overall, Purple Tree markets its product as the world’s purest electrolyte drink that gives the body the cleanest mineral salts, essential trace elements, and fast-acting electrolytes.

The supplement is free from sugar, something that’s uncommon in other hydration supplements. Purple Tree is based in San Diego, the US, and its hangover supplements range from $15 to $35 per bottle.


The Sobur hangover supplement claims to help users never to have another hangover. The supplement protects the brain and body after heavy drinking and stops hangovers. Once taken, the users can wake up feeling healthy and energized.

Sobur delivers many of the ingredients of other top-ranked hangover pills on this list to achieve the benefits. Key ingredients in this formula include DHM, Vitamin C, N-acetyl, L-carnitine, and B vitamins. They work together to eliminate hangover-causing toxins such as acetaldehyde.

In addition to fighting hangovers, Sobur claims to combat issues with blood sugar levels, dehydration, and other aftereffects of drinking. Sobur is currently priced at $35 for a packet of 20 capsules, which amounts to 10 servings. This makes it one of the competitively priced supplements on this list.

Fewer Regrets

Like most hangover supplements on this list, Fewer Regrets promises to help users live their lives with fewer regrets. While it cannot eliminate all regrets, it delivers eight natural ingredients to combat the effects of a hangover. The supplement contains green tea extract, turmeric extract, milk thistle, and prickly pear, among other popular ingredients.

Some of these ingredients are associated with antioxidant effects and other health benefits. Other ingredients can support the liver naturally. The supplement is currently priced at about $50 for 12 servings, higher than competing mid-range options listed here.

How We Ranked the Best Hangover Pills

While each hangover supplement claims to stop a hangover, not all of them deliver the expected results. Only the best hangover pills work. Here are the metrics we used to rank the hangover supplements:

Proven Ingredients

Hangovers have been there for as long as anybody can imagine. Some cures have worked for centuries, while others are advanced science—this list of preferred hangover remedies with proven ingredients and effective dosages.


Since individuals react to alcohol differently, it’s not easy to scientifically test hangover supplements in a controlled setting. However, many major hangover supplement manufacturers mention clinical trials to prove their remedies work as advertised to fight hangovers. This list considered hangover supplements that went through clinical trials with extensive reference pages.

Manufacturer Reputation and Transparency

Some hangover supplement manufacturers have an established reputation for developing quality products. Some even have long standing medical advisory boards in place. This list preferred reputable manufacturers with transparency regarding their work.

Price and Value

Some customers can spend up to $50 to prevent a hangover. Others would just want to part with $1-$5 for the same. This list features hangover pills with different price ranges while emphasizing value at every point. This ensures customers get the most value for their money.

Ease of Use

Most hangover pills are simple and easy to take. Users just need to pop the pill, and that’s it. Others are blended with water, so they’re available in liquid form. This list considered supplements that are easy to use even on the go.

Moneyback Guarantee

People process alcohol in different ways, and this may call for different results for each user. A B vitamin supplement is enough for some users to stop a hangover, while others require herbal extracts, inflammatory plant extracts, or adaptogens. Most of the best hangover pills come with a money-back guarantee. This list features products that supported their claims with customer satisfaction or a moneyback guarantee.

Hangover Pills: Do they have side effects?

Hangover supplements don’t pose any adverse health risk when used by healthy adults in standard dosages. The primary use of a hangover pill is to prevent the side effects of drinking. However, some users could be allergic to an ingredient or more used in making a supplement.

In that situation, the user might experience an allergic reaction to certain ingredients, including herbal or plant extracts. Similarly, some users might experience digestive discomfort after using a hangover supplement, especially for the first time.

The same can happen when a user takes too much of a particular supplement. All the same, these reactions are always mild and insignificant. Users should expect no significant side effects when using a hangover supplement.

Hangover Pill Dosages

Hangover supplements are made from various ingredients and work in different ways. It’s always advisable to follow the recommended dosage instructions given by the manufacturer for each hangover pill. Most supplements require users to take one or two capsules. Others require consumers to take one or two packets.

However, hangover supplement manufacturers recommend using higher dosages for heavy drinking or partying adventures, such as double the standard dosage. Even so, users should not take more than one or two dosages of a hangover supplement unless advised by the manufacturer or a health expert.

Hangover Pills: What does science say?

Most hangover supplements are not supported by detailed scientific evidence. Most companies don’t invest in clinical trials or scientific studies. Instead, they rely on third-party studies done on the ingredients and dosages contained by the hangover pills.

Some of the best-rated hangover supplements cite dozens of references to support their claims. Others use peer-reviewed research papers and clinical trials to back their claims. This ranking considered products that had more substantial scientific evidence to back their claimed benefits.

For instance, FlyBy is one of the few hangover supplement manufacturers with a published clinical trial on its product. According to the trial, researchers found the supplement effective against hangover-causing toxins.

Similarly, hangovers result from a harmful toxin, Acetaldehyde, which accumulates in the body as one drinks. It’s the reason why people feel gross the morning after drinking. Due to the presence of this toxin, hydration alone cannot prevent a hangover. Most top-rated hangover supplements contain ingredients that can fight this toxin by flushing it from the body or neutralizing its effects.

Some people also attribute alcohol’s hangover effects to being diuretic. This implies that alcohol makes one urinate quite often—in large quantities. This further removes nutrients, vitamins, and minerals from the body. To recover the lost water and nutrients, one needs to replenish the lost vitamins, minerals, and nutrients. For this reason, many hangover supplements deliver the proper nutrients in the right quantities for rehydrating the body after drinking.

Milk thistle is another common ingredient in hangover formulas. This ingredient has been shown to alleviate liver disease by delivering multiple health benefits to the organ. For example, some studies have shown that as an antioxidant, it can block toxins at the membrane level, improve protein synthesis, and deliver anti-inflammatory effects, among others.

Milk thistle seemingly works because it has an active ingredient known as silymarin. This ingredient claims to have the ability to stop toxins from attaching to liver cells. It also combats free radicals, which may arise during drinking or processing alcohol. While more research is needed to confirm the effects of milk thistle on liver health, many have already shown it could help support the organ in different ways.

Many hangover supplements contain electrolytes to help users rehydrate the body after drinking. During a workout or drinking adventure, the body loses large amounts of essential electrolytes like calcium, sodium, chloride, and potassium. Without replacing the lost electrolytes, the person is likely to experience a hangover.

In the end, hangover research is still growing. However, available research validates the claims of several hangover supplements.

Your Questions Answered: FAQs About Hangover Pills

Here are some of the questions people ask about the best hangover supplements and pills:

Q: What is a hangover?

A: A hangover is a combination of symptoms that arise from drinking too much alcohol. It comes with headaches, fatigue, nausea, stomach pain, anxiety, and sensitivity to light and sound.

Q: Why do hangovers happen?

A: Scientifically, no one knows precisely how hangovers work, why they happen, or why some people experience worse hangovers than others. However, this condition generally occurs due to the effect of alcohol, as it removes crucial minerals and vitamins from the body. This eventually causes dehydration. According to some studies, inflammation, immune response, and other problems could cause a hangover.

Q: Why does alcohol cause a hangover?

A: Alcohol acts as a diuretic. It increases urine production, which flushes out minerals from the body. The body also processes alcohol into toxic compounds, which affects normal body functions.

Q: What is acetaldehyde?

A: Acetaldehyde is a toxic compound that forms when the body processes alcohol (ethanol). Most top-rated hangover supplements contain acetaldehyde-targeting ingredients to deal with this toxin.

Q: Why is the level of hangover different in people?

A: The level of a hangover in a person could vary based on genetics, lifestyle habits, physiology, drinking habits, and many more. Besides, science doesn’t explain why some people would experience worse hangovers than others. Some individuals are also prone to hangovers while others are not.

Q: Do some drinks cause worse hangovers than others?

A: The eventual cause of a hangover is alcohol. The more alcohol one consumes, the more likely a person can experience a hangover. On the same note, drinks with higher alcohol content can cause worse hangovers. Other studies have also linked sulfites in wine to hangovers, which is why wines can cause worse hangovers than other beverages.

Q: How can one prevent hangovers?

A: The best way to combat a hangover is to take a hangover pill, eat on a full stomach, and avoid drinking too much alcohol within a short period. It’s equally important to stay hydrated throughout the night.

Q: What is the best way to cure a hangover quickly?

A: According to some studies, taking an electrolyte formula or drinking a hydration beverage can help cure the effects of drinking, such as hangovers. Traditionally, some communities have also used remedies like eating shrimp (Mexico), pickled herring (Germany), and pickled plums (Japan).

Q: When is a hangover most high?

A: Hangover symptoms max out when the user’s blood alcohol concentration returns to nearly zero. The symptoms can last almost 24 hours.

Q: Are hangovers dangerous?

A: People are different, and hangovers can be dangerous based on individual reactions to alcohol. With poor muscle coordination, attention, and response times, it’s dangerous to operate a machine or drive under the influence of alcohol.

Q: What is the best hangover pill?

A: The best hangover pill is any among the pills and supplements listed here. This list contains top-rated hangover supplements and pills available on the market today.

Best Hangover Supplements in 2021 Final Word

To sum up, nobody likes a hangover. Fortunately, the advancements in the supplement industry have led to the creation of hangover pills and supplements. Users can drink without worrying about any aftereffects of alcohol. By taking the right hangover supplement or pill, users can stop the worst effects of alcohol and resume their happy and productive days. This list provides the way to get started with the best hangover supplements on the market in 2021.

ALSO READ: Best Immunity Booster Supplement for a Healthy Immune System

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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