Best Immunity Booster Supplements for Immune System Support

The immune system is your natural defense against anything that will enter and attack your body. If it is healthy, then you are healthy.

There are lucky enough people to have naturally robust immune systems and others that are so poor they need medical information. Most of us fall somewhere in between.

A healthy diet and lifestyle help boost our body’s immunity, and SUPPLEMENTS can be an integral part of this. Considering the amount of international travel and global exposure to illness we are up against today, supporting our natural immunity is more critical than ever.

Unfortunately, hundreds of supplements claim to support immunity. The scientifically PROVEN individual supplements that are best for our immunity are plants, Vitamin C, and zinc. Many immune-boosting supplements on the market do not work as advertised and may not have enough of those ingredients to be considered beneficial.

With this in mind, here is our list of some of the best immunity boosters of 2021.

Best Immunity Booster Supplements

The following rankings are a culmination of RESEARCH on lab reports and manufacturers alike to ensure we can present the peak in immune system support supplements for 2021.

VitaPost Immune Support

image 11

Top Ingredients- Beta-Glucans, Quercetin, Green Tea, Vitamin E, Vitamin C, Arabinogalactan, and Olive leaf Extract.

How It Can Benefit Your Body-

Maintain and energize your immune system.

Better immune response to fight pathogens and diseases.

Avoid iron deficiency and anemia.

Improve the count of white blood cells.

Lower your risk of heart disease.

Dosage-2 capsules a day, or consult a medical professional.

Guarantee- Not Offered.

Price $13.95.

According to the makers of this supplement, VitaPost’s Immune Support uses botanical extracts to support and nourish your immune system. It has more than a dozen scientifically backed ingredients in its formula. The elements include potent antioxidants and are considered one of the best immune support supplements available today.

The antioxidants in VitaPost Immune support lower the risk of having heart disease and certain cancers. It has Beta glucans which are among the best ingredients for a robust immune system. Moreover, the mushroom complex has more mushroom power to strengthen the immune response. On top of all, it’s incredibly affordable and highly effective at boosting your overall immune system.

Visit The Official Website Now.

Mushroom Defense

image 8

Top Ingredients- Maitake, Turkey Tail, Chaga, Royal Sun Agaricus, White ButtonCordyceps Sinensis, Reishi, Shiitake, Lion’s Mane, and Black Fungus.

How It Can Benefit Your Body-

Energize immune function and defense response.

Improve the supply of antioxidants in your body.

Improve your mental health.

Offer healthy gut health.

Slower aging effects and avoid memory loss.

Dosage-Consult healthcare professional.

Guarantee-67 day money-back guarantee.

Price- $59.99

Mushrooms are known for many health benefits, not least of which include fighting fatigue, protecting you from cognitive decline, and supporting the immune system. Hence, it’s no wonder the makers of Mushroom Defense saw fit to make a supplement complex based on this superfood. Specifically, they advertise their product to protect against bacterial and viral-related health problems and support cognitive function and energy levels.

Their formula includes a rare mushroom extra from a mountainside village outside of Sao Paulo, Brazil. With a 67-day refund policy, it’s hard to find a reason not to try this immunity support if you are looking for the best available complex.

Visit The Official Website Now.

VitaPost Immune Complex

image 10

Top Ingredients- Turmeric, Vitamin C, Vitamin E, Vitamin B6, Zinc, L-Glutamine, and Elderberry fruit extract.

How It Can Benefit Your Body-

Supply powerful antioxidants.

Give you healthy skin and eyesight.

Maintain blood pressure and heart rate.

Avoid depression and poor brain functioning.

Control blood uric acid levels.

Dosage- 2 capsules a day with water (30 minutes before going to bed).

Guarantee- Not Offered.

Price $17.95.

As this company’s second supplement on our list, the VitaPost immune Complex supplement differs significantly from its predecessor. This formula has a different approach to supporting immunity; the most proven immune-supporting natural ingredients: Elderberry, echinacea, and probiotics. Echinacea is often taken by people who are or looking to prevent being sick. However, studies show that elderberry can shorten the length of the flu or cold symptoms, and probiotics are essential for the digestive tract’s healthy functions.

We now know up to 70% of the immune system lies in the gut, so supporting gut health is vital to a healthy immune system. Furthermore, Vitamin C in this immune support supplement helps prevent iron deficiency. If you have tight schedules and finding trouble following a healthy lifestyle, you must consider this supplement.

Visit The Official Website Now.

Zenith Labs Nano C

image 13

Top Ingredients- Natural orange flavor, Vitamin C, and Water.

How It Can Benefit Your Body-

Boost and repair your body tissues.

Enhance wound healing properties.

Improve your bone and teeth health.

Keep you away from the common cold and infectious diseases.

Dosage- Consume one dropper in the morning for consecutive 30 days.

Guarantee- Money-back Guarantee of 180 days.

Price- $49.

Vitamin C is probably the most common ingredient of any immune-supporting supplement formula. Still, Dr. Ryan Shelton of Zenith Labs has created a new, bioavailable version called Nano C Immune Support. Rather than the pill form, Nano C is taken via daily drops, with a high dose of nature’s best antioxidant- Vitamin C.

Dr. Shelton and Zenith Labs supplements are unique because the Vitamin C is in a nano form, about 1,000 times smaller than how it is found in nature, thereby combating the absorption issue many vitamin supplements come up next. They claim their supplement will fortify your immune system while shortening recovering time from various common sicknesses.

Visit The Official Website Now.

Epishield Plus

image 4

Top Ingredients-Vitamin C, Vitamin D, Epicor, Shiitake mushroom, and Chaga Mushroom.

How It Can Benefit Your Body-

Boost the body’s natural defense and innate immunity.

Help fighting upper respiratory infections.

Give protection against the common cold and flu.

Make your muscles and bones healthy.

Avoid having heart disease.

Dosage-2 to 3 times a day or talk to a medical professional.

Guarantee- Money-Back Guarantee for 365 days.

Price- $49.

Simple Promise’s Epishield Plus claims to boost the immune system within the first two hours of trying it. Like other supplements on this list, it includes Vitamin D and C and extracts from the mushroom that is helpful to mend immune dysfunction. But its unique ingredient is fermented yeast, added to boost and maintain an allegedly healthy and robust immune system. Each bottle is quickly sold out, which is a good indication of its popularity levels.

Visit The Official Website Now.

Advanced Bionutritionals Resistol

image 1

Top Ingredients- Platycodon, Eleuthero, Andrographis, Prickly Chaff Flower, and Licorice.

How It Can Benefit Your Body-

Make your skin healthy and glowing.

Boost lung functioning and immune cells.

Support the immune system and fight free radicals that can cause inflammation.

Improve brain functioning.

Reverse aging signs.

Dosage-2 capsules a day.

Guarantee- 90 days money-back guarantee.


Resistol uses the five herbs featured in the formula that have been studied for their positive effects. Many take them daily for their benefits and immune response. The Andrographis is a scientifically proven ingredient to support a healthy immune system. Moreover, Eleuthero root supports the human lymphatic system to keep the body’s fluid balanced and avoid infection or inflammation.

Their unique approach to herbs and Poland extracts instead of straight vitamins like the other supplements on this list makes them worthy of trying all independently. Resistol is one of the affordable as well as effective immune support supplements for the everyday user.

Visit The Official Website Now.

Organixx 7M

image 9

Top Ingredients- Lion’s Mane, Shiitake, Chaga, Maitake, Cordyceps, Reishi, and Turkey Tail.

How It Can Benefit Your Body-

Help fighting viral and bacterial infections.

Treat aches and pains.

Give you robust gut health.

Protect from inflammation.

Help to get a strong immune system.

Dosage- 2 capsules a day with water or juice.

Guarantee- 365 days money-back guarantee.

Price- $55.

Organixx 7M not only contains mushroom extracts like some others on this list, but it also explicitly has the shiitake, reishi, and maitake mushrooms in its formula. These three mushrooms are known for their benefits to your immune system, but they also contain beta-glucans that are supposed to be anti-inflammatory antioxidants. This supplement includes the 7m uses cordyceps, lion’s mane, and turkey tail mushroom extracts in smaller amounts. Organixx recommends daily usage for healthy digestion, immune functions, and inflammation control.

Visit The Official Website Now.

BioShield MD

image 2

Top Ingredients- Curcumin Extract, Tart Cherry Extract, Cocoa Extract, Boswellia Serrata, and Resveratrol.

How It Can Benefit Your Body-

Cure poor immune function.

Energize body, mind, and immune system.

Give relief from joint pain due to overwork.

Enhance thinking capacity and brain functioning.

Fight with aging signs.

Dosage-2 times a day with/without a meal.

Guarantee- 365-day guarantee.

Price- $49.95.

Created by Dr. Mark Rosenberg of Sun Coast Sciences, BioShield MD is a supplement claiming to support immunity. Energy, joints, mental health, and more using clinically effective doses. Along with dozens of low-dose ingredients, BioShield has substantial, clinically proven amounts of tart cherry extract, improving sleep, endurance, and reducing systolic blood pressure.

An extract of coca stimulates stomach function and improves your overall gut health. Rich with antioxidants and flavonoids, this supplement should support your immune function from multiple angles.

Visit The Official Website Now.

VitaPost Turmeric & Ginger

image 12

Top Ingredients- Ginger extract, Organic Turmeric, and peppercorn extract.

How It Can Benefit Your Body-

Powerful anti-oxidant and anti-inflammatory properties.

Support joint health.

Help minimizing allergies.

Provide a solid respiratory system.

Control blood sugar and heart functioning.

Dosage- Consume one capsule two times a day before 23-minutes of taking a meal.

Guarantee- Not Offered.

Price- $23.95.

VitaPost’s Turmeric & Ginger is a high-end blend of Turmeric and Ginger, aiming to flood your body with antioxidants and boost healthy immune function. As two of the most popular foods in the health community and eastern medicine communities, turmeric and ginger have been used for a long time to support healthy immune system function while also promoting overall health.

Each capsule contains 100 mg of organic ginger and 500 mg of organic turmeric, with an added 50mg dose of turmeric and a 5 mg dose of black pepper extract. This supplement is one of the more reasonably priced supplements on this list, making it well worth trying if you are unsure of its usefulness.

Visit The Official Website Now.

Immuno Defense 4x

image 7

Top Ingredients- Quercetin, Whole Food Fermentate, Vitamin D, and Bromelain.

How It Can Benefit Your Body-

Higher antibody and t cells count.

Lower chronic inflammation.

Restrict viruses and pathogens.

Decrease risk of respiratory infections.

Improve breathing.

Dosage- 2 capsules once a day.

Guarantee-60 day money-back guarantee.

Price $44.95.

JayLab Pro’s Immuno Defense 4x provides substantial doses of its four main ingredients- 500 mg EpiCor, 500 mg quercetin, 150 mg bromelain, and 166% of your DV of vitamin D3. This supplement is the second on our list to include EpiCor, a type of dried yeast extract. This element provides you with energy and helps maintain healthy hair, eyes, skin, and mouth.

Furthermore, Quercetin is a powerhouse of natural nutrients which is essentially helpful to treat illnesses like Zika and the Ebola virus. Impressive? Indeed, and while not the cheapest on the list, it has scientific studies backing its ingredients. It is one of the best immunity boosters you must get if you deal with low immunity and working tiredness.

Visit The Official Website Now.

Doctor G’s Naturals Q-Ion Immune Defense

image 3

Top Ingredients- Bromelain, Camellia Sinensis Extract, Zinc, and Quercetin.

How It Can Benefit Your Body-

Channelize the detoxification process in the body.

Fight with viral and bacterial infections.

Prevent body aches and innate immunity.

Better zinc absorption to neutralize free radicals.

Fuel your immune cells.

Dosage- 1 capsule a day.

Guarantee- Money back guarantee of 60 days.

Price $79.95.

One of the few on this list claims to protect against dangerous pathogens, a tall and probably unrealistic order. Doctor G’s Q-Ion Immune Defense claims their formula acts as a potent anti-inflammatory to support antiviral and immune health in your body. However, it is one of the few doctor-approved supplements here (always to be taken with a grain of salt as that label only requires a single doctor to approve it officially).

Doctor G’s Naturals was created by board-certified physician Dr. John, with Dr. Gordon using his expertise to add zinc, bromelain, quercetin, and green tea extract to the formula. This supplement also includes Ion-Blast Technology, which adds to the bioavailability of zinc and quercetin, essentially making them absorb better and faster.

Visit The Official Website Now.

Immunity 911

image 5

Top Ingredients- Himalayan Raspberry, Graviola Leaf, Himalayan Pomegranate, Olive Leaf, and Mushroom Blend.

How It Can Benefit Your Body-

Make healthy white blood cells to fight invaders.

Antioxidants to mitigate cell damage.

Lower chronic stress and inflammation.

Provide T cells to improve immunity.

Improve digestive system functioning.

Dosage-2 capsules a day with water.

Guarantee- 90-day money-back guarantee.


PhytAge Labs claims their Immunity 911 supplement uses a wide range of ingredients to support the immune system. PhytAge Labs guarantees their product will work. It contains lower doses of vitamin C than other immune-supporting supplements to support immune function better. Also, it has substantial amounts of red raspberry fruit extract that avoid having a chronic illness.

This blend includes ancient herbs like turmeric, pine bark, burdock, sheep sorrel, grape seed extract, cat’s claw, and garlic. Yea, it sounds like many ingredients, but customers finding the Immunity 911 a source of a healthy lifestyle. While confident in what they offer, their lack of transparency does make it difficult to verify.

Visit The Official Website Now.

Immunity Formulas Immune Support

image 6

Top Ingredients-Peppermint, Cinnamon, Bioperine, Turmeric, Lemon, and Oregano.

How It Can Benefit Your Body-

Disinfect and purify the air of your room.

Build the body’s immunity naturally.

Give protection from viral and bacterial infection.

Improve the Antioxidant level.

Ensure a better immune system function.

Dosage-Apply topically, diffuse, or disinfect.

Guarantee-Not Offered.

Price $64.99.

Immunity Formulas Immune Support has a unique blend of herbal essential oils in its formula, claiming to solve virus and immune-related problems, including boosting the body’s natural defense, supporting the immune system, purifying the air, and sanitizing surfaces.

Their most vital ingredients include oregano, lemon, peppermint, cinnamon, and turmeric essential oils. While studies show essential oils can support the immune system in small ways, others have no evidential support of this claim, so whether it will help you remains to be seen.

The second thing that makes the Immunity Formulas Immune Support supplement different is its ability to be spread on the skin or diffused in the air, rather than being found in pill form. So if you struggle with swallowing large pills or want to switch it up, this may be the product for you.

Visit The Official Website Now.

How We Ranked The Best Immune Supplements

All immunity booster supplements have similar claims and often even similar ingredients. So how do we rank them or decide which are the best immunity boosters for you?

The Science

First, we look at any scientific evidence for the ingredients behind these claims. For example, vitamin C and D, probiotics, Zinc, and elderberry extract have substantial scientific evidence showing benefits to the body and, specifically, the immune system.

It would be ideal to look at studies on the supplements themselves, but because the supplement industry is not FDA regulated in the United States, there is rarely a study to back them up.

Dosage, Dosage, Dosage

Unfortunately, the lack of regulation means a supplement could contain everything it claims to, all the right things, but not be at a dose that is effective in any way. It’s essential to look for supplements with science-backed dosage amounts, valid for any supplement you are looking to take.

No Illegal Lying

One part of the supplement industry that the FDA regulates to prevent extreme and life-altering fraud is the claim to be a cure. It’s important to choose supplements claiming to support good health or different parts of the body, not claim to be the cure-all or prevent-all to diseases and cancers. This is mainly because of COVID. With this new disease, there has been a flood of illegal supplement advertising online claiming to protect you from it or cure you of it- never fall for it.


Any supplement you consume should be from a known manufacturer with a known location and appropriately certified facilities. Authoritativeness is not just roundabout transparency in business issues; it’s literally about safety. We are often putting these supplements directly into our bodies.

We need to know where they are coming from and follow the appropriate health guidelines when making their products. We always prefer companies with the most transparency possible.

Medical Advisory Board

Want to know if you’re buying from a highly qualified supplement provider? See if they employ a medical advisory board at their company staffed with certified medical doctors and scientists. Preferably, the entire board, but definitely at least the majority of it. It’s no accident that the healthiest, safest, and most likely to work supplement blends have medical professionals involved in their inception.


Does the manufacturer even have a good reputation? Some companies pump out many products, and most or all have bad reviews. We looked to see if this was the case with these supplements, and so should you. We prefer a manufacturer with a long and established history, but at least not a bad history, even if that means using a product from a newer company. Using a quality supplement limits the likelihood of being conned by someone in it to make a quick dollar off of you.


It is ideal when a company transparently lists where their ingredients are sourced, mainly if they use a unique element not often seen in other supplements of that nature.

Price vs. Value

Hopefully, we were able to provide you with a range of choices when it comes to cost. We all have different budgets and wanted to keep that in mind. We tried to pick some of the best from each end of the price range to show you can have good value at any price.

The Science Behind the Ingredients

If you don’t particularly care about science, feel free to skip this section, but we encourage everyone to care about what science says about what we are taking to try and be healthier.

Studies support some things making a difference in immune function and being crucial to overall health. Here are the most common or most visible immune support ingredients on this list and what the science says about them:

Vitamin C

Probably the most popular ingredient, numerous studies support the positive effects of Vitamin C. The National Institutes of Health makes it clear we need this vitamin to synthesize L-carnitine, certain neurotransmitters, and collagen. As an antioxidant, it targets disease-causing free radicals throughout the body, with some studies showing it helps prevent or delay cancer growth. Because our regenerative ability must create connective tissue, it also dramatically impacts our natural healing abilities.

Vitamin D

Those deficient in this vital vitamin have a more impaired immune function and many other problems ranging from insomnia to depression to muscle soreness. It’s linked with an increased risk of infection and autoimmunity issues. They even used it to treat infections in the not-so-distant past (before antibiotics) because we could see it had positive effects even then. Vitamin D can also be obtained from sunlight and foods.

Vitamin E

Vitamin E is a nutrient that is naturally available in foods like almonds, wheat germ, spinach, broccoli, etc. Vitamin E boosts the immune systems of all humans, so it is an essential element to add to our diet. It helps to improve cell function and widen blood vessels, so you don’t have blood clotting.


Protein is crucial for several healthy body functions, not least of which is a healthy immune system. While the above supplements mostly don’t contain protein, it seemed worth noting how vital this is to our readers. You can obtain protein from foods like soy products, foul, eggs, fish, beef, pork, nuts, beans, dark green vegetables, and yogurts. Protein becomes an amino acid in the body which is highly vital for healthy immune function. 70% of the immune system is in the gut, specifically your intestinal cells.


Zinc is an antioxidant with anti-inflammatory effects, and studies show people with less than the average healthy adult present a higher risk of developing the infectious disease. Obtained from food, zinc deficiency is also associated with a flawed immune system. Even if you are uninterested in immune-supporting supplements, people not getting enough Zinc through their diets should seriously consider a zinc supplement.


Although a trendy supplement, probiotics are crucial to a healthy gut fauna, and we have already established that 70% of the immune system is in the gut. Probiotics are not just beneficial for the immune system, though. It seems like discovery is made; showing a healthy heart is vital for some healthy functions. Probiotics have been linked to immune-related diseases and viral infections, with some studies showing they can help treat or prevent seasonal allergies.


Elderberry has been used in Europe for centuries as a herbal remedy for the common cold and flu. It has shown to be beneficial for treating fever, which was ideal before creating more potent medications. Some doctors recommend increasing cold and flu recovery (though it should not be relied on when having severe symptoms, including COVID). Science says Elderberry is rich in Vitamin C. One study had 60 adults take 15 mL of elderberry syrup 4x a day, with everyone experiencing improved symptoms up to 4 days earlier over the placebo group.


Much like Elderberry, echinacea has also been used for centuries as a medicinal plant. Science has since validated the positive results in supporting the immune system. One study found short-term use shortened the duration and lessened the severity of upper respiratory infections and colds. It appears to only be effective after the onset of symptoms; otherwise, it’s just a tea ingredient.


An ingredient of traditional eastern medicines for centuries, today we know ginger to be a powerful antioxidant and anti-inflammatory. Much like garlic, it also has antibacterial and antiviral properties.


Another antioxidant, turmeric, is rich in curcuminoids which are linked to anti-inflammatory properties. However, this study showed turmeric activating immune cells, which is a wholly different benefit to the immune system than just as an antioxidant. Turmeric is poorly absorbed into the system unless paired with black pepper extract, which increases its bioavailability by 2,000%, which is something to keep in mind if you’re looking to add it to your daily supplement routine.

Best Immunity Booster Supplements-Final Thoughts

Everyone should consider taking supplements to support healthy body functions, including the immune system. All immune systems supporting supplements use similar vitamins, minerals, or plant extracts to help keep you healthy. There are plenty of studies to back up these ingredients, and you should consider adding something to your daily routine, whether through one of these supplements or diet choices.

Hopefully, this list has taught you how to pick out your immunity booster supplements, the basics of what you need, and has encouraged you to give something on this list a try that fits your needs, wants, and budget. In these uncertain times, it’s more important than ever to make sure we take care of ourselves and help our immune system protect us. Try one of the best immunity booster supplements in 2021 today!

RELATED:Best Mushroom Supplements: Top Brands for Pills and Powders

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

Sound Publishing, Inc. does not accept liability for any loss or damages caused by the use of any products, nor do we endorse any products posted in our Marketplace.