Best Nerve Pain Supplements – Top Supplements for Neuropathy

Do you often feel a tingling sensation, icy hot driving needles, burning sensation in your extremities? If yes, you might be suffering from neuropathic pain.

But, what does neuropathy mean?

Neuropathy is a medical condition used to define an injury or dysfunction of one or multiple body nerves. It usually occurs as a problem in the peripheral nervous system: the network of neurons outside the brain and spinal cord.

Neuropathy’s most common presentation is tingling, numbness, irritation, burning or shooting pain, and muscle weakness in the affected area. Neuropathy is a common disease that affects about 8% of people above 65 years of age.

Neuropathy can occur due to many causes. But it mainly occurs as a complication of chemotherapy, alcoholism, amputation, diabetes, HIV, shingles, and others. Research shows nerve damage occurs in about 65% of people with diabetes, causing diabetic neuropathy.

Some of the causes of neuropathy include:

  • Physical injury to the nerve is the most common cause of neuropathy. It might occur due to falls, sports injuries, accidents, and broken or dislocated bone.
  • About 50% of diabetic patients suffer from peripheral neuropathy. It may occur due to damage to the blood vessels that supply different nerves of the body. Diabetic neuropathy mainly affects the arms and legs.
  • Some autoimmune disorders such as rheumatoid arthritis, Guillain-Barre syndrome, and Sjogren syndrome also cause neuropathy.
  • Carpel tunnel syndrome is a common type of neuropathy that occurs due to nerve damage caused by repetitive movements over time.
  • Blood circulation disruptions can also affect different nerves of the body. Excessive smoking narrows your blood vessel and cause neuropathy.
  • Some other causes include chemotherapy, cancer, hormonal disturbance, infections, and drugs.

Neuropathy is a debilitating condition that can affect your productivity and daily life activities. Fortunately, we can manage symptoms and the underlying etiology of neuropathy.

We can manage neuropathic pain via multiple methods such as physical therapy, relaxation therapy, massage therapy, and acupuncture; however, the first line of management is supplements.

There are many supplements available in the market, which claim to cure neuropathy. However, all of these are not similarly effective and curable for everyone.

12 Best Supplements For Managing Neuropathy

We have formulated a list of the best supplements for neuropathic pain. This list is based on multiple ranking factors such as essential ingredients, dosages, manufacturer reputation, proven effects, etc.

Let’s quickly dive into the details of each neuropathic supplement.

Nuturna Maximum Strength Neuropathy Support Formula


Nuturna Maximum Strength Neuropathy Support Formula is our first choice because of some practical reasons. You will get 600mg of Alpha Lipoic Acid (ALA), the most potent dose recommended for treating neuropathy. It also contains 15 organic ingredients that include vitamin B12, thiamine, carnitine, and benfotiamine.

The formula increases the blood flow to the nerves and supplies essential nutrients to activate biochemical pathways for nerve regeneration and growth. A review suggests that vitamin B helps in nerve repair.

Also, studies conducted in 2015 and 2017 reveal the effect of benfotiamine in decreasing pain and improving diabetic neuropathy.

The Nuturna Maximum Strength Neuropathy Support Formula is budget-friendly, easy to swallow, and free from strong and offensive flavors, making it one of the best-selling supplements in 2021.

Nerve Control 911


PhytAge Labs, one of the reputed companies, makes Nerve Control 911.

It contains natural ingredients for neuropathy pain treatment. A miracle root from Malaysia, marshmallow root, and passionflower are present in this innovative formula.

The company claims that this supplement targets pain from diabetic neuropathy, improves muscle control and strength, reduces inflammation, and improves signal transmission from the central nervous system to the body parts.

The official website of PhytAge Labs suggests Nerve Control 911 can treat extreme conditions as well. For example, a woman suffering from extensive nerve damage and warned by doctors for limb amputation fixed her problem with Nerve Control 911 supplements within a few days.

Nerve Renew Advanced Nerve Support


Nerve Renew supplement by Life Renew is a broad-spectrum formula. It is beneficial for the cases of diabetic neuropathy, nerve damage, Lyme disease, nerve degeneration, acute and chronic inflammation, and vitamin deficiency.

The two capsules of nerve Renew daily flood your nerve with antioxidants to ease nerve pain, tingling, and burning sensation. It contains alpha-lipoic acid to improve blood flow, vitamin B for nerve repair, and Vitamin D for bone support.

The best feature is bioavailability three times greater than other formulas in our list, increased effectiveness, and instant action.

Nerve Rejuv


Golden After 50 has added alpha-lipoic acid, turmeric, herbal extracts, vitamins, minerals, and amino acids in Nerve Rejuv to benefit nerve damage. It is a natural formula for healing damaged nerves by reducing pathogens that cause inflammation.

It is specially made for old age people with or without diabetes. Nerve Rejuv can regenerate torn nerves, reduces numbness, tingling, pins and needles sensation, and pain from neuropathy.

Nerve Rejuv can also treat the pain related to fibromyalgia and shingles. Take two capsules of Nerve Rejuv daily for relieving your nerve pain.



Nervala by Barton Nutrition is a secret recipe for relieving tingling, numbness, and shooting pain. The company claims that it ‘cools down’ your burning nerves by Nervala supplements and prevents it from ‘overheating engines.’

Nervala supplements also fight against the root cause of pain-free radicals that cause inflammation. It contains two unique ingredients; 600mg alpha-lipoic acid and 75mg benfotiamine in standard dosages as doctors recommend.

They offer you a zero-risk purchase by giving you a money-back guarantee. Try Nervala to get rid of pain and repair your nerves.

Natura Clinical Strength Neuropathy 900


Nature offers substantial doses of active ingredients in Neuropathy 900. It contains 900mg of alpha-lipoic acid, a heavy dose of l-arginine, organic turmeric root, acetyl-L-carnitine, and other herbs. The 900mg of ALA is the maximum dose that none of the other tablets can offer.

This best-selling product gives you a combination of 18 ingredients in a single formula to fight your nerve damage and improve your immune system. It is bioavailable, easy to swallow, and doctors formulated formula.

Neuro Calm Pro


Neuro Calm Pro is an innovative supplement by researcher Gerard Watson. It has different ingredients and modes of action than other formulas on our list. You will be amazed to know that it supports nerve health by targeting your ear.

Its ingredients include saw palmetto, fenugreek extract, L-tyrosine, and wild yam to calm irritated nerves.

Neuro Calm Pro can help you with tinnitus, damaged nerves, numbness in extremities, and other types of nerve pains. You will get an audio clip to soothe your nerves and relax your mind on purchasing this supplement. If you are unsatisfied with the formula, you can get a refund.



Nervexol is a neuropathy support formula with powerful natural ingredients. The flowers, herbs, barks, vitamins, and unique ingredient calamarine are added to support you and relieve your nerve pain.

Calamarine is a super nutrient from the deep sea, rich in omega-3 fatty acid that supports your brain, nerves, and joint health. The company claims that this formula does wonder in reducing your burning, stinging and tingling sensation.

It nourishes and strengthens nerve linings, improves your balance and coordination.

Circle Labs CBD


Circle Lab has various CBD products such as CBD balms, creams, and tinctures to help relieve your pain. CBD interacts with your body’s endocannabinoid system, such as CB1 and CB2 receptors present in body cells.

The CBD pain and tension balm, CBD/CBDa tincture, 3x strength CBD pain stick, and other products contain organic jojoba oil, frankincense, beeswax, and essential citrus oil. These ingredients help relieve arthritis pain, stiff muscles and joints, neuropathic pain, and other conditions.

It is a unique method of nerve pain relief than others in this list, but customer reviews suggest that Circle Labs CBD is beneficial and effective for nerve pain control.

Nervogen Pro


Nervogen Pro is a simple but powerful formula developed by medicinal chemist Kevin Miller. It is a mixture of five ingredients added in smaller doses than other supplements.

It includes passiflora incarnata, corydalis yanhusuo, California poppy seeds, prickly pear, and marshmallow root.

The manufacturer claims that Nervogen Pro may relieve nerve pain, tingling, and numbness. We have considered this supplement because of the low dosages of ingredients added at a high price.

Bonus Nerve Pain Guide# 1: Neuropathy No More By Jodi Knapp


Neuropathy No More is an e-book released by Blue Heron Health News and written by Jodi Knapp. According to him, neuropathy is a choice, and we can manage it by simple lifestyle changes and diet modification.

According to the author, you can be free from neuropathy if you choose this e-book and apply its treatment plan. Simple lifestyle adjustments can help you relieve neuropathic pain without the need for supplements.

Neuropathy is a complex disease; Neuropathy No More treatment plan may not benefit everyone. However, you can get your money back with a 60-day refund policy if this treatment plan does not help you.

Bonus Nerve Pain Guide #2: Neuropathy Revolution


Mark Fellers, the author of the book Neuropathy Revolution claims to fight your diabetic pain in just 30 days. There is a seven-step holistic method to end peripheral neuropathy regardless of a chronic condition and diabetic nerve pain. You can dramatically decrease your pain severity in as little as 24 hours.

To promote their product, the company is offering you a bonus eBook with the name diabetes protocol. This book can help you treat and fix the root cause of diabetes type 2.

The author also offers a money-back guarantee; if this 100% natural and safe plan does not work, you can get your money back.

How We Rank Neuropathy Pain Supplements

All the neuropathic supplements claim to reduce and treat nerve pain. But are all these supplements worth spending money on? No, because not all supplements contain beneficial ingredients, and many supplements do not contain the ingredients in recommended dosages.

We know it is challenging to find the best supplement for your nerve pain; therefore, we have prepared a list of the best neuropathic pain relievers based on the following ranking factors.

Essential Ingredients

According to the research, there are various ingredients beneficial for alleviating nerve pain. Some of the proven ingredients are extracts of herbs, fruits, flowers, ALA, vitamins, and minerals. We rank supplements that contain the best and research-proven ingredients for neuropathy treatment.

Effective Dosages

Ingredients are only effective when added in standard dosages. If supplements contain less dosage, they are ineffective. We include those medications in our list that have the correct dosages of ingredients as it increases the efficiency and safety of the supplement.

Medical Advisory Board

Some supplement manufacturing companies invest in their medical advisory board. If certified doctors, nutritionists, or other medical professionals are on the medical advisory board, we consider those products as reliable and include them in our list.

Companies Reputation

Supplement manufacturing companies’ reputation matters. Many supplements in our list are from companies with a long-standing record of producing reliable and safe supplements. We prefer well-recognized and reputable companies.

Customer Reviews

Reviews build faith and loyalty for future customers. The supplements with a proven record of beneficial effects, reducing nerve pain, and treating neuropathy are included in our list of best neuropathy supplements. Customer reviews help you choose the best supplement as per your condition.

Cost-Effective Supplements

We consider those supplements in our list that are budget-friendly and offer good value of money. Best neuropathy supplements can cost between $20 to $100, but these should be beneficial and effective in treating your neuropathy.

Whether you want to purchase in a few dollars or hundred dollars, you will get the supplements in your budget.

Company Transparency

Some companies are transparent in disclosing all the ingredients present in the supplements, dosages, benefits, and risk factors, while others are not. To compare different formulas and chose the best, we must know everything about the product.

We consider those companies that do not hide dosages and ingredients with their customers.

Benefits And Side Effects

Along with the benefits, supplements may also have some side effects on the body. The best supplement is one that offers more pros and poses no or minimum side effects. We recommend you weigh the advantages and cons of each supplement you use.

Money-Back Guarantee

Many products on this list offer you a money-back guarantee and return policy. The root cause and condition of every patient are different. Therefore, the treatment of each case may vary. We prefer those companies that offer a refund policy for their customers.

These are some of the significant factors that we use to rank products in our list of best neuropathy supplements.

What Are The Benefits Of Neuropathy Supplements

The mode of action of neuropathy supplements depends upon the active ingredients that are included in the supplements. Active ingredients in neuropathy supplements are alpha-lipoic acid, vitamins, acetyl-l-carnitine, and others. These are the primary ingredients that treat neuropathy and reduce symptoms.


Acetyl-l-carnitine is an antioxidant and amino acid found naturally in meat, fish, poultry, and dairy products. Your liver and kidney also produce it. It can make your nerve cells healthy, reduce nerve pain and enhance body energy. The optimum dose effective in treating neuropathy is 500mg twice a day.

A review suggests that acetyl-l-carnitine can help reduce the symptoms of diabetic neuropathy by reducing inflammation.

Alpha Lipoic Acid

Alpha-lipoic acid (ALA) is an antioxidant that lowers sugar levels, reduces nerve pain, and helps minimize tingling, numbness, and burning pain in your extremities.

Alpha-Lipoic acid (ALA) reverses the impact of oxidative stress, reduces protein glycosylation, and increases ATPase activity in nerve cells to promote the normal functioning of nerves.

Alpha-lipoic acid is naturally found in broccoli, liver, red meat, spinach, brewer’s yeast, etc. Research shows that 600mg of ALA once daily provides diabetic nerve pain relief at clinically measurable levels.

Vitamin B

Many neuropathy supplements contain vitamin B, such as vitamin B6 and vitamin B12. Vitamin B12 deficiency in the body is associated with polyneuropathy and tingling in the lower extremities.

Vitamin B in neuropathy supplements block damaging metabolic pathways, activate protein synthesis, and modulate neural excitability. It helps in nerve repair, regeneration, neurogenesis, and neuroprotection.


Foundation for Peripheral Neuropathy suggests the function of magnesium in reducing neurotoxicity. Another study published by Nutrients suggests reduced neuropathy symptoms in patients undergoing chemotherapy who have a more significant magnesium level in the body.


Glutathione is an antioxidant that can reduce nerve pain symptoms in patients with chemotherapy-induced neuropathy, diabetic neuropathy, and other similar conditions. Therefore, many companies add glutathione to neuropathy supplements.

California Poppy

California Poppy is present in some of the supplements on our list. It is a powerful herb that helps relieve burning sensation, tingling, shooting pain, and inflammation associated with neuropathy.

Prickly Pear Cactus

The Prickly Pear Cactus contains many antioxidants that fight against free radicals to reduce inflammation in your body. It is used for treating diabetes, obesity, high cholesterol, and nerve pain.

In addition to the above supplements, research proves that lifestyle modification and diet can also manage neuropathy. Taking a warm bath can soothe your irritated nerves and increase blood circulation, thus reducing nerve pain and numbness. Simple exercises can help lower blood sugar levels and increase blood flow to the extremities, thus reduces discomfort and pain.

If you are a smoker, then quitting your smoking habit can also alleviate the symptoms of neuropathy. Smoking narrows your blood vessels and reduces blood circulation to various parts of your body. If you quit smoking, then it will improve blood flow and can improve your symptoms.

Frequently Asked Questions (FAQs) About Neuropathy Supplements

Q. What is neuropathy?

A: Neuropathy is a chronic condition that is the result of damage or dysfunction of nerves. It causes tingling, numbness, or burning sensation in the affected areas. It is a prevalent condition affecting about 20 million Americans.

Q. What is peripheral neuropathy?

A: Peripheral neuropathy is a condition caused due to the damage of peripheral nerves. It causes weakness, pain, tingling, and numbness in the extremities.

Peripheral neuropathy is one of the most commonly occurring complications of diabetes mellitus.

Q. What is diabetic neuropathy?

A: Diabetic neuropathy is a condition that causes injury to the nerves due to high blood sugar. It occurs in patients with diabetes mellitus. About 50% of people with diabetes suffer from nerve pain. Diabetes most commonly causes small fiber neuropathy in which the patient feels a painful burning sensation in the upper and lower extremities.

Q. What are the symptoms of neuropathy?

A: Neuropathy affects the productivity and daily life activities of an individual. A few of the symptoms include pain, numbness, tingling, burning, and weakness in the hands and feet. Many patients suffering from neuropathy feel pins and needles sensation.

Q. What are the causes of neuropathy?

A: Neuropathy is caused by the dysfunction of the nerves in your body. The nerves send and receive signals from the brain and spinal cord to different parts of the body. When the nerves are destroyed these signaling mechanisms are affected and cause neuropathy symptoms.

Q. what is the difference between mononeuropathy and polyneuropathy?

A: Mononeuropathy is a condition that affects a single nerve, while polyneuropathy affects multiple nerves. Carpal tunnel syndrome is one of the types of mononeuropathy. The most common type of polyneuropathy is diabetic neuropathy.

Q. Does neuropathy develop quickly?

A: Some neuropathies develop rapidly within a few weeks or months; however, others take years to develop. There are above 100 types of neuropathies, and each develops differently. How quickly it develops depends upon the type of nerve dysfunction and its underlying causes.

Q. How is neuropathy treated?

A: There are multiple approaches to treat or manage neuropathy; all depends on your condition. Some doctors recommend neuropathy supplements or physical therapy. Others recommend lifestyle modification, immune suppression or immune-modulating treatment, acupuncture, transcutaneous electrical nerve stimulation (TENS), or laser therapy. Most of these treatments improve neuropathy symptoms and help mask the effects on an individual’s life.

Q. Is neuropathy surgery a helpful treatment option?

A: Doctors recommend a nerve decompression procedure to manage neuropathy. It is an outpatient treatment approach that requires small incisions over the affected area. It relieves the pressure points on nerves that may be the cause of neuropathy symptoms.

Q. Which nerves are affected by neuropathy?

A: Neuropathy affects three types of nerves that make the peripheral nervous system of your body.

Motor Nerves: Motor nerves are present in the central nervous system and control conscious movements such as walking. They carry the signals from your brain towards the muscle to move.

Sensory Nerves: sensory nerves transmit sensory information from your five senses to the central nervous system. These nerves travel in the opposite direction to the motor nerves.

Autonomic Nerves: Autonomic nerves control involuntary or subconscious body functions such as heart rate, digestion, blood pressure, sweating, and breathing.

Q. What are different approaches to diagnose neuropathy?

A: Neuropathy is diagnosed using various methods. Some doctors diagnose with the help of patient history, symptoms, and medical examination. Some prefer body fluid tests, nerve conduction velocity (NCV), and genetic tests (if the genetic cause is suspected).

Other diagnostic approaches include a nerve biopsy, magnetic resonance imaging (MRI), neurodiagnostic skin biopsy, and electromyography (EMG) test.

Q. Is neuropathy preventable?

A: Neuropathy is preventable in many cases. Mainly neuropathy occurs due to diabetes, and you can prevent diabetes with simple measures. Also, reducing weight, lifestyle modifications, and eating a healthy diet helps prevent neuropathy. You must consult your medical professional to know more about preventive strategies as per your condition.

Q. Is neuropathy associated with genetics?

A: There are over 100 types of neuropathic conditions, and some of them occur due to genetics. Charcot-Marie-Tooth disease is a type of neuropathy and a genetic nerve disorder.

Q. What is the mode of action of neuropathy supplements?

A: Most neuropathy supplements have ingredients that improve blood circulation and reduce inflammation. Other neuropathy supplements flood the body with herbs, amino acids, flower extracts, and other essential nutrients that help relieve nerve pain.

Q. What serious consequence can occur due to untreated peripheral neuropathy?

A: Patients with peripheral neuropathy feel numbness in their feet, due to which you cannot feel injuries. Lack of care of the injured area can lead to limb amputation in severe cases.

Q. Which supplement is best for neuropathy?

A: Any of the supplements from our list is best to treat your neuropathy. However, we recommend consulting your doctor before starting any medication. Always choose supplements that offer more significant benefits with minimum side effects.

Q. Can I reverse neuropathy?

A: Yes, you can reverse neuropathy if it is diagnosed early. If the underlying etiology of neuropathy is treated (neuropathy due to vitamin deficiency), it is possible to reverse neuropathy as well. However, most neuropathies are diagnosed at later stages.

12 Best Supplements For Managing Neuropathy Conclusion

Neuropathy is a chronic condition causing tingling, burning pain, shooting pain, and numbness in the affected area. The cause of neuropathy is nerve damage or dysfunction.

You can manage neuropathy with the help of several supplements. However, not all supplements are beneficial and safe for you.

We have prepared a list of top neuropathy supplements considering ranking factors such as essential ingredients, dosages, company reputation, pricing, etc.

This list is not an alternative to medical advice. We recommend you consult a health professional to choose the best treatment for yourself. Always select the supplement that gives you more benefits with minimum side effects.

RELATED: Nerve Rejuv Reviews – Do Golden After 50 Nerve Health Pills Work?

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